CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator

Abstract BCL-2 inhibitors such as venetoclax offer therapeutic promise in acute myeloid leukemia (AML) and other cancers, but drug resistance poses a significant challenge.It Fuser Assembly is crucial to understand the mechanisms that regulate venetoclax response.While correlative studies have identified numerous genes linked to venetoclax sensitiv

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Symptom without transcendental syntax

This paper aims at investigating the Freudian symptom as an individual anti-language involved in a semiotic antagonism towards the internal logonomic system.In Freudian-Lacanian psychoanalysis, the symptom is interpreted according to transcendental and atemporal principles.Leaving aside these principles, we argue for a social semiotic approach in w

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